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| 产品编号 | KMH1394 |
|---|---|
| 产品名称 | Recombinant Human Mesothelin/MSLN Protein, His Tag |
| 产品描述 | Recombinant Human Mesothelin/MSLN Protein, His Tag (KMH1394) contains the human MSLN(Glu296-Ser598) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
| 分子名称 | MSLN |
| 产品别称 | MPF, SMRP, mesothelin |
| 规格 | 50ug, 100ug |
| 物种 | Human |
| 宿主 | Mammalian cells |
| 蛋白家族 | Other protein |
| 编录号 | Q13421 |
| 纯度 | ≥90% as determined by SDS-PAGE |
| 内毒素水平 | < 1.0 EU per ug of the protein as determined by the LAL method. |
| 缓冲体系 | PBS |
| 分子量 | 33.33 kDa |
| 纯化方式 | Affinity Purification |
| 产品背景 | Mesothelin (MSLN) was initially cloned from a library of human pancreatic cancer cells. It was also identified by a monoclonal antibody, MAb K1, which recognized a glycoprotein present on the surface of mesothelial cells. Mouse and human mesothelin are 69% identical. Mouse MSLN gene encodes a ~71 kD precursor protein of 625 amino acids. The C-terminal glycosylphosphatidylinositol (GPI) anchor addition signal is removed and replaced with a GPI anchor. The MSLN precursor is cleaved by furin into two products, a ~31 kD mature megakaryocyte potentiating factor and a ~4 kD GPI-anchored membrane-bound mature mesothelin. The 4 kD GPI-anchored mesothelin can be released by treatment with phosphatidylinositol-specific phospholipase C. Soluble mesothelin specifically binds to ovarian carcinoma cell line OVCAR-3, mediated by the cancer antigen 125 (CA125), a mucin-like glycoprotein on the surface of tumor cells. |
| 保存条件 | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
