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| 产品编号 | KMH245 |
|---|---|
| 产品名称 | Recombinant Human CD80 Protein, His Tag |
| 产品描述 | Recombinant Human CD80 Protein, His Tag (KMH245) contains the human CD80(Met1-Asn242) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
| 分子名称 | CD80 |
| 产品别称 | B7, BB1, B7 1, B7.1, LAB7, CD28LG, CD28LG1, CD80 molecule |
| 规格 | 50ug, 100ug |
| 物种 | Human |
| 宿主 | Mammalian cells |
| 蛋白家族 | CD molecule |
| 编录号 | P33681 |
| 纯度 | ≥90% as determined by SDS-PAGE |
| 内毒素水平 | < 1.0 EU per ug of the protein as determined by the LAL method. |
| 缓冲体系 | PBS, pH7.5 |
| 分子量 | 28.52 kDa |
| 纯化方式 | Affinity Purification |
| 产品背景 | It is widely accepted that T cells require a signal induced by the engagement of the T cell receptor and a "costimulatory" signal(s) through distinct T cell surface molecules for optimal T cell expansion and activation. Members of the B7 superfamily of counterreceptors were identified by their ability to interact with costimulatory molecules found on the surface of T cells. Members of the B7 superfamily include B7-1 (CD8), B7-2 (CD86), B7-H1 (PD-L1), B7-H2 (B7RP-1), B7-H3 and PD-L2. B7-1 is expressed on activated B cells, activated T cells, mature dendritic cells and macrophages. T cells express two different receptors capable of binding B7-1, CD28 and CTLA-4. CTLA-4 binds to B7-1 with a 2 - 1 fold higher affinity than CD28. Engagement of CD28 by B7-1 increases T cell proliferation and IL-2 production and enhances the immune response. In contrast, engagement of CTLA-4 is involved in the down-regulation of the immune response. Rat and human B7-1 share 47% amino acid identity. |
| 保存条件 | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
