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| 产品编号 | KMP2241 |
|---|---|
| 产品名称 | Cynomolgus TNFRSF17 Protein, His Tag |
| 产品描述 | The Cynomolgus TNFRSF17 Protein(KMP2241) is produced in HEK293 Cells and the target gene encoding Met1-Ala53 is expressed with a 6His tag at the C-terminus. |
| 物种 | Cynomolgus |
| 宿主 | HEK293 Cells |
| 规格 | 50ug, 100ug, 200ug |
| 纯化方式 | Affinity purification |
| 内毒素水平 | <1.0 EU/ug determined by the LAL method |
| 缓冲体系 | 50mM Tris, 100mM Glycine, pH7.5 |
| SDS-PAGE |  |
| 产品背景 | B cell maturation antigen(BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation. |
| 保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| 说明 | This product is for research use only. |
