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| 产品编号 | KMP3046 |
|---|---|
| 产品名称 | Human CD247 Protein |
| 产品描述 | The Human CD247 Protein(KMP3046) is produced in E. coli. The target gene encoding the human CD247 (P20963-1) (Arg52-Arg164) is expressed. |
| 分子名称 | CD247 |
| 产品别称 | T细胞表面糖蛋白CD3 Zeta链, Human CD247 Protein, CD247 |
| 物种 | Human |
| 宿主 | E. coli |
| 规格 | 50ug, 100ug, 200ug |
| 纯度 | >90% as determined by SDS-PAGE |
| 纯化方式 | Affinity purification |
| 内毒素水平 | <1.0 EU/ug determined by the LAL method |
| 缓冲体系 | 50mM Tris, 150mM NaCl, pH7.5 |
| 产品背景 | CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. |
| 保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| 说明 | This product is for research use only. |
