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| 产品编号 | MOP2168 |
|---|---|
| 产品名称 | Recombinant Mouse Gitr/Tnfrsf18 Protein, Fc & His Tag |
| 产品描述 | Recombinant Mouse Gitr/Tnfrsf18 Protein, Fc & His Tag (MOP2168) contains the mouse Tnfrsf18(Ser22-His153) was fused with the C-terminal Fc-His Tag and expressed in Mammalian cells. |
| 分子名称 | Tnfrsf18 |
| 产品别称 | AITR, Gitr, tumor necrosis factor receptor superfamily, member 18 |
| 规格 | 50ug, 100ug |
| 物种 | Mouse |
| 宿主 | Mammalian cells |
| 蛋白家族 | Other protein |
| 编录号 | O35714 |
| 纯度 | ≥90% as determined by SDS-PAGE |
| 内毒素水平 | < 1.0 EU per ug of the protein as determined by the LAL method. |
| 缓冲体系 | PBS |
| 分子量 | 39.52 kDa |
| 纯化方式 | Affinity Purification |
| 产品背景 | GITR (glucocorticoid-induced tumor necrosis factor receptor) also known as TNFRSF18, is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells.1 GITR is involved in the regulation of T-cell receptor mediated cell death. Constitutive expression of a transfected GITR gene induces resistance to apoptosis induced by anti CD3 monoclonal antibodies. GITR ligand interferes with the suppressor activity of CD4(+) CD25(+) regulatory T-cells. |
| 保存条件 | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
