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产品编号 | KMP2789 |
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产品名称 | Human TIGIT Protein, His Tag |
产品描述 | The Human TIGIT Protein(KMP2789) is produced in CHO Cells. The target gene encoding the human TIGIT (NP_776160.2) (Met22 - Pro141) is expressed with a polyhistidine tag at the C-terminus. |
分子名称 | TIGIT |
产品别称 | T细胞免疫球蛋白, Human TIGIT Protein, His Tag, TIGIT |
物种 | Human |
宿主 | CHO Cells |
规格 | 50ug, 100ug, 200ug |
纯度 | >90% as determined by SDS-PAGE |
纯化方式 | Affinity purification |
内毒素水平 | <1.0 EU/ug determined by the LAL method |
缓冲体系 | PBS, pH7.4 |
产品背景 | TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-1 and diminished the production of IL-12p4. Also, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition. |
保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
说明 | This product is for research use only. |
编号 | 产品名称 | 物种 | 宿主 | 应用 | 规格 | 询价 |
---|---|---|---|---|---|---|
Antibody drug target protein | Recombinant Human TIGIT Protein, His Tag | Human | Mammalian Cells | 50μg, 100μg | ||
KMPH2439 | Human TIGIT Protein, His Tag | Human | HEK293 Cells | 10ug, 50ug | ||
MOP1752 | Mouse TIGIT Protein, Fc Tag | Mouse | HEK293 Cells | 50ug, 100ug | ||
MOP1753 | Mouse TIGIT Protein, His Tag | Mouse | HEK293 Cells | 50ug, 100ug | ||
KMPH5903 | Human TIGIT Protein, Fc Tag | Human | HEK293 Cells | 10ug, 50ug | ||
KMPH5904 | Human TIGIT Protein, His Tag | Human | HEK293 Cells | 10ug, 50ug | ||
KMPH5905 | Human TIGIT Protein, Fc Tag | Human | HEK293 Cells | 10ug, 50ug | ||
KMPH5906 | Human TIGIT Protein, His Tag | Human | HEK293 Cells | 10ug, 50ug | ||
KMH515 | Recombinant Human TIGIT Protein, His Tag | Human | Mammalian cells | 50ug, 100ug | ||
KMH1805 | Recombinant Human TIGIT Protein, His Tag | Human | Mammalian cells | 50ug, 100ug | ||
MOP2292 | Recombinant Mouse Tigit Protein, His Tag | Mouse | Mammalian cells | 50ug, 100ug | ||
MOP2293 | Recombinant Mouse Tigit Protein, His Tag | Mouse | Mammalian cells | 50ug, 100ug | ||
KMP2787 | Human TIGIT Protein, hFc Tag | Human | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP2788 | Human TIGIT Protein, hFc Tag | Human | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP2790 | Human TIGIT Protein, His Tag | Human | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP2791 | Human TIGIT Protein, His Tag | Human | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP2792 | Human TIGIT Protein, His Tag | Human | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP2793 | Human TIGIT Protein, mFc Tag | Human | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP2794 | Human TIGIT Protein, hFc Tag, Avi Tag | Human | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP2795 | Human TIGIT Protein, His Tag, Avi Tag | Human | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP3704 | Cynomolgus TIGIT Protein, hFc Tag | Cynomolgus | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP3980 | Mouse TIGIT Protein, mFc Tag | Mouse | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP4279 | Rat TIGIT Protein, hFc Tag | Rat | HEK293 Cells | 50ug, 100ug, 200ug | ||
KMP1110 | Recombinant Human TIGIT Protein | Human | HEK293 cells | 50ug, 100ug | ||
KMP1263 | Recombinant Mouse TIGIT Protein | Mouse | Mammalian | 50ug, 500ug | ||
KMP1816 | Recombinant Human TIGIT Protein | Human | HEK293 cells | 50ug, 100ug | ||
KMP1830 | Recombinant Human TIGIT Protein | Human | HEK293 cells | 50ug, 100ug | ||
KMP2129 | Biotinylated Recombinant Human TIGIT Protein | Human | Expi293 | 100ug, 500ug | ||
KMP2139 | Recombinant Human TIGIT Protein | Human | Expi293 | 100ug, 500ug |