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| 产品编号 | KMP3380 |
|---|---|
| 产品名称 | Human LAG3 Protein, hFc Tag |
| 产品描述 | The Human LAG3 Protein(KMP3380) is produced in HEK293 Cells. The target gene encoding the human LAG3 (NP_002277.4) (Met1-Leu450) is expressed with the Fc region of human IgG1 at the C-terminus. |
| 分子名称 | LAG3 |
| 产品别称 | 淋巴细胞激活基因-3, Human LAG3 Protein, hFc Tag, LAG3 |
| 物种 | Human |
| 宿主 | HEK293 Cells |
| 规格 | 50ug, 100ug, 200ug |
| 纯度 | >95% as determined by SDS-PAGE |
| 纯化方式 | Affinity purification |
| 内毒素水平 | <1.0 EU/ug determined by the LAL method |
| 缓冲体系 | 20mM NaH2PO4, 150mM NaCl, 0.1M Arg, 0.1M Glu, 10% Glycerol, 0.01% Tween20, pH7.4 |
| 产品背景 | LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease. |
| 保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| 说明 | This product is for research use only. |
