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Recombinant Human EGFR Protein, His tag产品信息
产品编号 KMH495
产品名称 Recombinant Human EGFR Protein, His tag
产品描述 Recombinant Human EGFR Protein, His tag (KMH495) contains the human EGFR(Met1-Ser645) was fused with the C-terminal His Tag and expressed in Mammalian cells.
分子名称 EGFR
产品别称 ERBB, HER1, mENA, ERBB1, PIG61, NISBD2, epidermal growth factor receptor
规格 50ug, 100ug
物种 Human
宿主 Mammalian cells
蛋白家族 Antibody drug target protein
编录号 P00533
纯度 ≥90% as determined by SDS-PAGE
内毒素水平 < 1.0 EU per ug of the protein as determined by the LAL method.
缓冲体系 PBS, pH7.5
分子量 70.95 kDa
纯化方式 Affinity Purification
产品背景 As a member of the epidermal growth factor receptor tyrosine kinases subfamily, EGF R is a type Ⅰ transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR signaling plays a crucial role in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR homo- or hetero- dimerization, initiates subsequent tyrosine autophosphorylation and various downstream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling has been shown to exert actions on carcinogenesis and disease progression, and thus EGFR was proposed as a target for cancer therapy currently.
保存条件 Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
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