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Feline EGFR Protein, His Tag产品信息
产品编号 KMP3789
产品名称 Feline EGFR Protein, His Tag
产品描述 The Feline EGFR Protein(KMP3789) is produced in Insect Cells. A DNA sequence encoding the feline EGFR (A0A337S424) (Leu25-Ser645) is expressed with a polyhistidine tag at the C-terminus.
分子名称 EGFR
物种 Feline
宿主 Insect Cells
规格 50ug, 100ug, 200ug
纯度 >95% as determined by SDS-PAGE
纯化方式 Affinity purification
内毒素水平 <1.0 EU/ug determined by the LAL method
缓冲体系 20mM Tris, 300mM NaCl, 10% Glycerol, pH8.0
产品背景 As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
保存条件 Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
说明 This product is for research use only.
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