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Human EGFR Protein, His Tag产品信息
产品编号 KMP3475
产品名称 Human EGFR Protein, His Tag
产品描述 The Human EGFR Protein(KMP3475) is produced in HEK293 Cells. The target gene encoding the human EGFR (NP_001333870.1, Isoform vIII) (Met1-Ser378) is expressed with a polyhistidine tag at the C-terminus.
分子名称 EGFR
产品别称 表皮生长因子受体, Human EGFR Protein, His Tag, EGFR
物种 Human
宿主 HEK293 Cells
规格 50ug, 100ug, 200ug
纯度 >85% as determined by SDS-PAGE
纯化方式 Affinity purification
内毒素水平 <1.0 EU/ug determined by the LAL method
缓冲体系 PBS, pH7.4
产品背景 As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
保存条件 Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
说明 This product is for research use only.
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