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| 产品编号 | KMP2947 |
|---|---|
| 产品名称 | Human BTLA Protein, hFc Tag |
| 产品描述 | The Human BTLA Protein(KMP2947) is produced in HEK293 Cells. The target gene encoding the human BTLA (NP_001078826.1) (Met1-Thr134) is expressed with the Fc region of human IgG1 at the C-terminus. |
| 分子名称 | BTLA |
| 产品别称 | B和T淋巴细胞衰减因子, Human BTLA Protein, hFc Tag, BTLA |
| 物种 | Human |
| 宿主 | HEK293 Cells |
| 规格 | 50ug, 100ug, 200ug |
| 纯度 | >90% as determined by SDS-PAGE |
| 纯化方式 | Affinity purification |
| 内毒素水平 | <1.0 EU/ug determined by the LAL method |
| 缓冲体系 | PBS, pH7.4 |
| 产品背景 | BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1). |
| 保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| 说明 | This product is for research use only. |
