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Human BTLA Protein, hFc Tag, Avi Tag产品信息
产品编号 KMP2949
产品名称 Human BTLA Protein, hFc Tag, Avi Tag
产品描述 The Human BTLA Protein(KMP2949) is produced in HEK293 Cells. The target gene encoding the human BTLA (NP_001078826.1) (Met1-Thr134) is expressed with a C-terminal Fc region of human IgG1 tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
分子名称 BTLA
产品别称 B和T淋巴细胞衰减因子, Human BTLA Protein, hFc Tag, Avi Tag, BTLA
物种 Human
宿主 HEK293 Cells
规格 50ug, 100ug, 200ug
纯度 >95% as determined by SDS-PAGE
纯化方式 Affinity purification
内毒素水平 <1.0 EU/ug determined by the LAL method
缓冲体系 PBS, pH7.4
产品背景 BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).
保存条件 Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
说明 This product is for research use only.
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