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Mouse CD86 Protein, hFc Tag产品信息
产品编号 KMP3832
产品名称 Mouse CD86 Protein, hFc Tag
产品描述 The Mouse CD86 Protein(KMP3832) is produced in HEK293 Cells. A DNA sequence encoding the Mouse CD86 (NP_062261.3) (Met1-Glu245) is expressed with the Fc region of human IgG1 at the C-terminus.
分子名称 CD86
物种 Mouse
宿主 HEK293 Cells
规格 50ug, 100ug, 200ug
纯度 >95% as determined by SDS-PAGE
纯化方式 Affinity purification
内毒素水平 <1.0 EU/ug determined by the LAL method
缓冲体系 PBS, pH7.4
产品背景 CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.
保存条件 Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
说明 This product is for research use only.
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