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Recombinant Rat B7-2/Cd86 Protein, His Tag产品信息
产品编号 PO126
产品名称 Recombinant Rat B7-2/Cd86 Protein, His Tag
产品描述 Recombinant Rat B7-2/Cd86 Protein, His Tag (PO126) contains the rat CD86(Vla29-Lys247) was fused with the C-terminal His Tag and expressed in Mammalian cells.
分子名称 Cd86
产品别称 B7 2, CD86 molecule
规格 50ug, 100ug
物种 Rat
宿主 Mammalian cells
蛋白家族 Other protein
编录号 O35531
纯度 ≥90% as determined by SDS-PAGE
内毒素水平 < 1.0 EU per ug of the protein as determined by the LAL method.
缓冲体系 PBS
分子量 24.09 kDa
纯化方式 Affinity Purification
产品背景 B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 2 - 1 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.
保存条件 Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
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