w66最给力的老牌生物科技（天津）有限公司
400-621-6806
周一至周六
8:00-18:00
服务电话：400-621-6806
地址：天津市武清区国际企业社区A5号楼五层，301700
邮箱：
| 产品编号 | KMH1807 |
|---|---|
| 产品名称 | Recombinant Human TIM-3/HAVCR2 C-fc Protein, Fc & His Tag |
| 产品描述 | Recombinant Human TIM-3/HAVCR2 C-fc Protein, Fc & His Tag (KMH1807) contains the human TIM3(Ser22-Arg200) was fused with the C-terminal Fc and His Tag and expressed in Mammalian cells. |
| 分子名称 | HAVCR2 |
| 产品别称 | TIM3, CD366, KIM 3, SPTCL, TIMD3, Tim 3, TIMD 3, HAVcr 2, hepatitis A virus cellular receptor 2 |
| 规格 | 50ug, 100ug |
| 物种 | Human |
| 宿主 | Mammalian cells |
| 蛋白家族 | Other protein |
| 编录号 | Q8TDQ0 |
| 纯度 | ≥90% as determined by SDS-PAGE |
| 内毒素水平 | < 1.0 EU per ug of the protein as determined by the LAL method. |
| 缓冲体系 | PBS |
| 分子量 | 44.69 kDa |
| 纯化方式 | Affinity Purification |
| 产品背景 | Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFNgamma secretion and influences the ability to induce T cell tolerance in both mice and man. |
| 保存条件 | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
