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| 产品编号 | KMH513 |
|---|---|
| 产品名称 | Recombinant Human HAVCR2 Protein, His Tag |
| 产品描述 | Recombinant Human HAVCR2 Protein, His Tag (KMH513) contains the human HAVCR2(Met1-Arg200) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
| 分子名称 | HAVCR2 |
| 产品别称 | TIM3, CD366, KIM 3, SPTCL, TIMD3, Tim 3, TIMD 3, HAVcr 2, hepatitis A virus cellular receptor 2 |
| 规格 | 50ug, 100ug |
| 物种 | Human |
| 宿主 | Mammalian cells |
| 蛋白家族 | Antibody drug target protein |
| 编录号 | Q8TDQ0 |
| 纯度 | ≥90% as determined by SDS-PAGE |
| 内毒素水平 | < 1.0 EU per ug of the protein as determined by the LAL method. |
| 缓冲体系 | Supplied as solution form in 50 mM Tris-HCl, pH 8.0, 150 mM NaCl./Lyophilized from 50 mM Tris-HCl, pH 8.0, 150 mM NaCl. |
| 分子量 | 20.67 kDa |
| 纯化方式 | Affinity Purification |
| 产品背景 | Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFNgamma secretion and influences the ability to induce T cell tolerance in both mice and man. |
| 保存条件 | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
